Menene GnRH, yadda yake aiki, da jiyya tare da GnRH
GnRH wata alama ce ta hormone maida gonadotropin. Wannan hormone ya fito da hypothalamus a kwakwalwa.
Ayyukan GnRH suna aiki a kan masu karɓa a cikin glandan tsinkaya. GnRH ta nuna alamar gland shine ta saki hormon (hormone) mai yaduwar jigilar gonadotropin (FSH) da kuma hormone luteinizing ( LH ).
FSH da LH to aiki a kan ovaries a cikin mata da kuma gwaji a cikin maza.
Suna faɗakar da ovaries zuwa girma da kuma yaye qwai, kuma, a cikin maza, suna jawo gwajin su girma da kuma samar da kwayar halitta.
FSH da LH kuma suna motsawa ovaries da gwaji don sakin jimlar su.
- A cikin ovaries, estrogen, progesterone, da testosterone an samar.
- A cikin gwaji, ana fitar da testosterone da estrogen.
An saki GnRH a cikin ɓullolin kuma ba a ci gaba ba.
A cikin maza, waɗannan ƙwararrakin sun zo ne da kyakkyawan ƙimar.
A cikin mata, yawancin hanzari ya bambanta dangane da inda jiki ke cikin juyayi. Alal misali, kafin kwayoyin halitta, GnRH pulses ne mafi sau da yawa.
Sauran Sunaye don GnRH
- Lumeinizing hormone-sakewa hormone (LHRH)
- Hanyoyin maganin sautin-hormone-release
- Luliberin (magani mai dauke da kwayar da ke kama da GnRH cikin jiki)
- Gonadorelin (magani mai dauke da kwayar cutar kamar GnRH cikin jiki)
Jaraba tare da Gonadorelin
Gonadorelin magani ne wanda yayi kama da hormone GnRH cikin jiki.
Ana iya amfani dashi a gwajin likita ko a matsayin magani don jinkirin balaga ko rashin haihuwa.
Jaraba yawanci ya shafi samun injections na wannan hormone a wani lokaci.
Na farko, za ku sami zub da jini, kafin in allura tare da hormone.
Bayan haka, a wani lokaci, allurar gonadorelin da ke ƙasa da fata a cikin kayan mai daɗi.
Bayan haka, bayan an saita adadin lokaci, za a sake zubar da jininka.
Wannan tsari - allurar da aka zubar da jini - za a ci gaba. Sakamako za'a binciki sakamakon a cikin wani lab.
Wannan jarrabawa za a iya yi a cikin yara tare da jinkirin balaga ko babba tare da zubar da jini na damuwa.
Jiyya tare da Gonadorelin via Lutrepulse famfo
Mata da ba a yin amfani da su ba za a iya bi da su tare da gonadorelin ta hanyar tsawa ta Lutrepulse. Ana yin haka idan rashin GnRH shine dalilin sauvulation.
Mutanen da ba su samar da kwayar cutar ba kuma za a iya bi da su tare da famfo na Lutrepulse.
Wannan famfar ya ba da nau'in ma'auni kowace minti 90 a tsawon makonni.
Bayan magani ya fara, a cikin mata, yawanci yakan ɗauki makonni biyu zuwa uku don ovulation ya faru. Bayan watsiwar ruwa, magani yakan ci gaba da sauran makonni biyu ta hanyar luteal.
GnRH-a GnRH Agonists da Antagonists
A lokacin likita na IVF , likitanku na likita ya kamata kula da kwayoyin cutar. In ba haka ba, za a iya yin amfani da ƙwai a farkon wuri. Ba za a iya dawo da su ba kuma sun hadu a cikin tsarin embryology idan wannan ya faru.
Wannan shi ne dalilin da ya sa za ka iya buƙatar ɗaukar GnRH agonist ko GnRH antagonist.
Duk magungunan magunguna suna samar da jihar ta maza.
Bambanci tsakanin kwayoyi shine cewa GnRH agonist na farko ya haifar da karuwa a cikin hormones FSH da LH sannan sai su dakatar. Maigidan GnRH ba ya haifar da haɓakar farko.
A lokacin IVF, zaka ba da kanka injections na hormones FSH da LH don su daɗa ovaries don samar da qwai.
GnRH agonists sun hada da:
- Lupron
- Synarel
- Suprecur
- Zoladex
Masu haɗaka GnRH sun haɗa da:
- Antagon
- Ganirelix
- Orgalutran
- Wannan yarinya
Hakanan za'a iya amfani da magungunan GnRH don magance endometriosis da fibroids.
> Sources:
> Gonadorelin (Hanyar mai ciki, Hanyar injection). Bayanan Micromedex Dallain Bayanai Game da Masu Amfani [Intanit]. Lafiya na PubMed.
> Gonadotropin-Releasing Hormone. Kai da Hormones. Society of Endocrinology.
> Magunguna don Yarda Hanya: Jagora ga marasa lafiya. Ƙungiyar Amurkan Cibiyoyin Harkokin Ciniki.