Risks da Side Side of Medicine Injectable Drugs
Kafin fara magani tare da gonadotropins - wasu lokuta ana kiranta su masu injectable - likita ya kamata ya bayyana maka abubuwan da ke tattare da kullun da kuma hadarin magani. Kuna iya ɗaukar gonadotropins tare da Clomid , a kan kansu, a matsayin wani ɓangare na juzu'i na YUI , ko kuma wani ɓangare na juyayin IVF .
Gonadotropins kuma ana amfani dashi ga mata suna ba da qwai da kuma hanyoyin shayewa .
Yawancin tasirin cutar gonadotropin ne mai sauki, amma a wasu lokuta, wasu na iya zama mai tsanani har ma da barazanar rai.
Alamar mahimmanci! Ba dukkanin halayen kullun da haɗari ba an jera su a ƙasa. Idan kun fuskanci cututtukan sakamako mai tsanani, sababbin alamun bayyanar cututtuka, ko damuwa saboda kowane dalili, tuntuɓi likitanku. Bayanai a cikin wannan labarin ba zai maye gurbin shawara tare da likita ba.
Wadanne Magunguna Ana Ganin Gonadotropins?
Gonadotropins sune kwayoyi masu haihuwa wanda ke dauke da FSH, LH , ko haɗuwa na biyu (wanda ake kira manopausal gonadotropins, ko hMG). Hakanan sun hada da hormone hCG , wanda yake kama da LH.
Ana amfani da waɗannan hawan ta hanyar allura.
Gonadotropins za a iya samar da su a cikin wani layi ta amfani da fasahar DNA na recombinant , ko za a iya cire su kuma an tsarkake su daga fitsari na 'yan mata maza da mata masu juna biyu.
Sunan sunayen gonadotropins da aka yi amfani da fasahar DNA na recombinant sun haɗa da Gonal-F (rFSH), Follistim (rFSH), Puregon (rFSH), Luveris (rLH), da Ovidrel (RHCG).
Bravelle, Metrodin, da Fertinex sune sunayen sunaye na FSH.
Novarel, Pregnyl, da Farfesa sune hCG samo asali.
Sunaye masu suna na urinary da aka fitar da manopausal gonadotropins (haɗin FSH da LH) sun haɗa da Humegon, Menogon, Pergonal, Repronex, da Menopur.
Hanyoyin Gaba na Gonadotropins
Lura: Ƙididdigar da ke ƙasa suna kallon binciken da aka kwatanta da Gonal-F - wanda shine rFSH, an gina shi a cikin wani lab ta yin amfani da fasahar DNA recombinant - kuma urofollitropin, ko uFSH, wanda aka tsarkake FSH daga fitsari na mata masu matsananciyar mata. Ƙidaya na iya bambanta kadan daga miyagun ƙwayoyi zuwa miyagun ƙwayoyi, amma yawancin sakamako na gefen gonadotropin suna kama da su.
Hanyoyin da ake iya haifar da gonadotropins sun hada da:
- Ciwon kai (rFSH: 22%, uFSH: 20.2%)
- Nausea (rFSH: 13.6%, uFSH: 3.5%)
- Babban kamuwa da cututtuka na sama (rFSH: 11.9%, uFSH: 7.9%)
- Abokin na ciki (rFSH: 9.3%, uFSH: 12.3%)
- Gas (rFSH: 6.8%, uFSH: 8.8%)
- Cigaban sinus (rFSH: 5.1%, uFSH: 5.3%)
- Janar kyauta (rFSH: 5.9%, uFSH: 6.1%)
- Saurin yanayi (rFSH: 5.1%, uFSH: 2.6%)
- Acne (rFSH: 4.2%, uFSH: 2.6%)
- Tashin tausayi (rFSH: 4.2%, uFSH: 6.1%)
- Darajar riba (rFSH: 3.6%, uFSH: 0.0%)
- Pelvic rashin tausayi (rFSH: 2.5%, uFSH: 6.1%)
- Cutar da ke da mawuyacin jini ko riko (rFSH: 2.5%, uFSH: 0.9%)
- Vomiting (rFSH: 2.5%, uFSH: 2.6%)
- Ciwon gurasar injection, redness (rFSH: 2.5%, uFSH: 0.9%)
- Dizziness (rFSH: 2.5%, uFSH: 0.0%)
Risuka na Gonadotropins
Ovarian Hyperstimulation Syndrome (OHSS) : OHSS yana faruwa a lokacin da ovaries da ciki zama kumbura da ruwa. Har zuwa 10 zuwa 20 cikin 100 na mata za su ci gaba da zama mai kyau na OHSS, wanda zai yi la'akari da kansa. Yana da mahimmanci a bada rahotanni ga likitanku, don haka ta iya lura da ku a hankali.
Idan kuna da PCOS , kuna cikin haɗari mafi girma na bunkasa OHSS.
Mai tsanani OHSS yana faruwa a kasa da 1% na marasa lafiya. Tuntuɓi likitanku nan da nan idan kun fuskanci vomiting, zafi mai tsanani ko ciwo na pelvic, karfin gwaninta, ko mai tsanani.
Mace yawan ciki : Dangane da irin binciken da kake duban, yawan nau'o'i na yawa tare da magani na gonadotropin a ko'ina daga 2% zuwa 30%, tare da zuwa kashi 5% na uku ko haɓaka mai girma.
Gwajin gwaji sun gano cewa daukar ciki mai yawa ya faru 12 zuwa 14% na lokacin lokacin amfani da rFSH ko uFSH. Kula da hankali da kuma yin amfani da maganin mafi ƙasƙanci zai iya rage haɗarin.
Lokacin yin amfani da gonadotropins a lokacin IUI ko kadai, yana da wuya a sarrafa haɗarin da yawa fiye da lokacin da ake amfani dashi a lokacin IVF. A lokacin IVF, likitanku zai iya canja wurin amfrayo guda.
Idan kun damu game da hadarin yawancin, kuma kuna amfani da injectables a matsayin wani ɓangare na Yuro, za ku iya so ku tambayi likita game da mini-IVF .
Ovarian cysts : Ovarian cysts faruwa fiye da gonadotropins. Tare da rFSH, suna faruwa game da 15% na lokaci, kuma tare da uFSH suna faruwa game da 29% na lokaci.
Yawancin lokaci, sun yanke shawarar kansu. A cikin lokuta masu ban sha'awa, na iya buƙatar karin maganin.
Injection ta hanyar kamuwa da cuta : Wasu tsabta da taushi na al'ada ne, amma a lokuta masu ƙananan, shafin intanet zai iya zama kamuwa. Tuntuɓi likita idan ka lura a wurin da ke cikin inuwa mai zurfi, zafi mai zafi, kumburi, puss, wari, ko zafi mai tsanani. Har ila yau, idan ka sami zazzaɓi a kan 101, tuntuɓi likitanka.
Tsuntsauran ƙyama (ko karkatacciyar jima'i) : A cikin lokuta masu wuya (kasa da 2% na lokaci), ovary zai iya karkatarwa, rupture, ko zubar da jini, yana buƙatar yin amfani da kai tsaye. Wannan yana faruwa ne saboda ovary ya zama nauyi kuma yaɗa girman daga rinjayar.
Jiki na ciki : Rashin haɗarin ciki a ciki yana kara ƙãra yayin shan gonadotropins. Tsarin ciki yana iya zama barazanar rayuwa ko kuma yana iya buƙatar taƙama.
Ruwan jini : Mafi wuya (4.2 cikin 1,000) amma zai iya zama barazanar rayuwa.
Ƙara yawan jini ya haddasa hadarin ba kawai a yayin jiyya ba, amma, idan kunyi ciki, ya ci gaba da zama mafi girma a lokacin daukar ciki.
Idan ka fuskanci bayyanar cututtuka na yiwuwar jini - kumburi ko ciwo daya kafa, mai dumi a yankin da ya shafa, canzawa a launin fata (redness, bluish, ko kodadde) - tuntuɓi likitanka nan da nan.
Idan ka ci gaba da bayyanar cututtuka na embolism na wucin gadi - kwatsam na rashin ƙarfin numfashin zuciya, zafi ciwon zuciya da ke damuwa lokacin da kake ƙoƙarin yin numfashi mai zurfi ko kuma lokacin da kaji, jin haske ko raunana, hanzari, suturawa, zub da jini, Kaddarawa mai zuwa - sami taimakon likita nan da nan.
> Sources
Gonal-f (follitropin alfa don allura). Takardar bayani na Drug. http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20378scf015_gonal_lbl.pdf
Henriksson P, Westerlund E, Wallén H, Brandt L, Hovatta O, Ekbom A. "Tashin hankalin kwayar cutar huhu da ciwo na thromboembolism a cikin ciki bayan hadewar in vitro: nazarin giciye." BMJ. 2013 Janairu 15; 346: e8632. Doi: 10.1136 / bmj.e8632. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546085/
Hanyoyi na gefen Gonadotropins: Bayanin Gaskiya. Ƙasar {asar Amirka na Cibiyar Harkokin Ciniki.