Masu maganin GnRH sun zama magungunan injectable da suke amfani dasu a yayin bitar IVF . Suna hana yaduwa daga ciki, don haka likitanku zai iya dawo da qwai daga ovaries kafin a sake sakin su kuma "sun rasa."
Kada ka dame GnRH agonists - kamar Lupron - tare da GnRH antagonists. Magunguna na GnRH sun haifar da haɗuwa a cikin hormones na haifuwa sannan, bayan kwanaki da yawa, rufe waɗannan kwayoyin hormones.
Idan aka yi amfani dasu a lokacin gyaran IVF, suna bukatar a fara a kalla 'yan makonni kafin jiguwar magungunan IVF zata fara.
Masu gwagwarmayar GnRH ba sa haifar da haɓakar farko a cikin hormones. An fara ne bayan da IVF ya fara kuma ana iya ɗauka sau daya ko kullum don 'yan kwanaki. Saboda an dauki su don dan gajeren lokaci, suna haifar da ƙananan sakamako, don lokaci ya fi guntu.
Alamar mahimmanci! Ba dukkanin halayen kullun da haɗari ba an jera su a ƙasa. Idan kuna fuskantar matsalolin haɗari mai tsanani, sababbin alamun bayyanar cututtuka, ko damuwa saboda kowane dalili, tuntuɓi likitan ku. Bayanai a cikin wannan labarin ba zai maye gurbin shawara tare da likita ba.
Menene Magunguna Su ne GnRH Antagonists?
Akwai magungunan GnRH biyu na kasuwa a kasuwa: hanrelix acetate da acetate na cedrorelix.
Alamun sunaye na acetate na ganirelix sun hada da Antagon, Ganirelix, da Orgalutran.
Wannan yarinya shine sunan magungunan acetate.
Ana amfani da wadannan magunguna ta hanyar allura. Jiyya na iya haɗawa da allurar rigakafi, koyaswa kullum a kan kwanaki da yawa, ko kuma injections guda ɗaya da aka dauka kwanakin baya. Dukkan ya dangana ne akan shirin ku na IVF.
Masu gwagwarmayar GnRH sun fi tsada fiye da GnRH agonists, amma ƙarin farashin bazai yi tasiri ba tun lokacin da aka dauki masu tayar da hankali don lokaci mafi tsawo.
Har ila yau, wasu mata sun yi imanin cewa yawancin sakamako masu illa suna darajar ƙarin farashin.
Yayinda wasu likitocin haihuwa suka fi son GnRH agonists saboda sun kasance tsawon lokaci, bincike bai samu bambanci a cikin shekarun haihuwa tsakanin masu tsauraran ra'ayi da masu tayar da hankali ba. Yi magana da likitanka idan kana so ka yi la'akari da masu adawa da GnRH maimakon GnRH agonist.
Hanyoyi na gefen GnRH Antagonists
Dukkan aikin acetate da kuma aikin ganirelix acetate ta hanyar dakatar da ikon gland na iya samar da saki FSH da LH . Wannan yana haifar da matsanancin matsanancin lokaci, wanda zai haifar da tasiri. Yawan shafuka masu yawa da za ku iya fuskanta ya dogara da tsawon lokacin da kuke shan magani.
Sakamakon abubuwan da ake amfani da shi na cetrorelix acetate (Cetrotide) sun hada da:
- Abun ciki da zafi (4.4% a yayin da aka dauki kowace rana, 2.1% lokacin da aka ɗauka a matsayin kashi daya)
- Ciwon kai (1.3% tare da kashi na yau da kullum, 0% lokacin da aka ɗauka matsayin kashi daya)
- Nausea (1.3% tare da kashi na yau da kullum, 1.1% tare da kashi daya)
Hanyoyin da ke tattare da haɗarin acetate na ganirelix (Antagon, Ganirelix, Orgalutran) sun hada da:
- Abokin ciki tausayi da ovaries (4.8%)
- Ciwon kai (3%)
- Ruwan jini na jini (1.8%)
- Ciwon gurasar injection ko raɗaɗi (1.1%)
- Nausea (1.1%)
- Buga ciwo (1%)
Risuka na GnRH Antagonists
Rigar mutuwar : A lokacin nazarin asibiti, kashi 3.7% na ciki a ciki yayin da ake daukar acetate na ganirelix ya ƙare a cikin mutuwar tayi, ko har yanzu haihuwar.
Ko wannan an haɗa shi ne ga masu adawa da GnRH musamman, ko zuwa wasu magungunan IVF, IVF kanta, ko rashin haihuwa, ba a sani ba.
Haɗuwar haihuwar : Nazarin ya samo ƙananan haɗari na rashin haihuwa a ciki lokacin daukar ciki yayin ɗaukar acetate na ganirelix. Ko wannan an haɗa shi da wannan magani na musamman, wasu magungunan IVF, hanyoyin IVF da kansu, ko rashin haihuwa ba a sani ba.
Ovarian hyperstimulation syndrome (OHSS) : Ya faru a 2.4% na mata ana bi da tare da ganirelix acetate. OHSS ba ainihin lalacewar GNRH ba, amma ta hanyar gonadotropins ɗauka a lokaci ɗaya.
Nazarin sun gano cewa hadarin bunkasa OHSS yana da ƙananan ƙananan tare da masu tayar da hankulan GnRN idan aka kwatanta da maganin GnRH agonists.
Mai tsanani OHSS yana faruwa a kasa da 1% na marasa lafiya. Tuntuɓi likitanku nan da nan idan kun fuskanci vomiting, ciwo mai tsanani ko ciwo na pelvic, ƙima mai nauyi, ko mai tsanani.
> Sources:
CETROTIDE cerorelix (kamar yadda acetate). Drug Data Sheet. An shiga Fabrairu 4, 2014. http://www.medsafe.govt.nz/profs/datasheet/c/Cetrotideinj.pdf
Ƙungiyar Nazarin Turai da Gabas ta Tsakiya. "Sakamakon gwagwarmaya ta hanyar amfani da GnRH antagonist ganirelix ko wata yarjejeniya na GnRH agonist triptorelin don hana rigakafi na LH a cikin mata da ke jurewa daga jikinta." Hum Refrod . 2001 Afr 16 (4): 644-51. http://humrep.oxfordjournals.org/content/16/4/644.full?sid=3335d39c-68fd-455f-b948-e4ffa2a70b66
Ganirelix Acetate Injection. Farin bayani na Drug. Merk. An shiga Fabrairu 4, 2014. http://www.merck.com/product/usa/pi_circulars/g/ganirelix/ganirelix_pi.pdf
Ragni G, Vegetti W, Riccaboni A, Engl B, Brigante C, Crosignani PG. "Ganin kwatankwacin magungunan GnRH da masu tayar da hankali a cikin jigilar haifuwa na marasa lafiya a babban haɗari na ciwo na hyperstimulation na ovarian." Hum Refrod . 2005 Satumba 20 (9): 2421-5. Epub 2005 Mayu 12. http://www.ncbi.nlm.nih.gov/pubmed/15890731