Tsarin yana ƙara yawan samfurori masu amfani
Ƙaddamarwa ƙayyadaddun lokaci ne da masana kimiyya ke amfani da su wajen bayyana yadda za a rage ko kawar da mayar da martani ga jikin mutum.
Idan aka yi amfani da shi tare da yin la'akari da hadewar in vitro (IVF) , sauƙaƙe da gaske sun "kashe" ovaries don kula da kwayar halitta da kwai maturation a lokacin magani.
Akwai nau'o'in miyagun ƙwayoyi guda biyu da aka yi amfani dashi don wannan dalili: GnRH agonists da masu adawa da GnRH.
Wani mutum ne mai maganin kwayoyi wanda ya haifar da amsa, yayin da abokin gaba ya zama nau'in da zai kaddamar da amsa.
Duk da yake hanyoyin da aka yi don maganin kwayoyi biyu sun bambanta, suna aiki ne ta hanyar hana jikin jikin mutum na kwayoyin halitta wanda ya haifar da ci gaban kwai da ƙwaya. Ta wannan hanyar, sun saukar da tsarin tsarin aikin physiological na ovaries.
Me ya sa ake amfani da Dokar Ƙasa a lokacin IVF Jiyya
Your ovaries dauke da dubban follicles . Kowace jaka yana dauke da kwai kwai ko oocyte.
A farkon lokacin sake zagayowar ku, hormone na Luteinzing (LH) da kuma hormone mai ban sha'awa (FSH) ke haifar da tsari na maturation a cikin rukuni na masu tsalle. Yayinda ƙwayoyin suke fara girma, za su saki sauran kwayoyin hormones don tsara tsarin LH da FSH-wani lokacin har sama, wani lokacin sau da yawa-har sai an halicci kwayoyin halitta.
Ovulation yawanci yana ƙunshe ne kawai kwai ɗaya. Bayan da aka sake yakin wannan ƙwayar, duk sauran ƙwayoyin a cikin wannan rukuni sun bushe kuma suka mutu.
Tare da IVF, likitanku ba ya so wannan ya faru. Maimakon haka, maƙasudin zai zama sauƙi don daidaita wannan amsa don haka:
- Yawancin nau'o'i suna iya haifar da mai yiwuwa, balagagge kwai.
- Gwairan suna kasancewa a cikin ɓoye don su iya samun sauƙin girbe.
Drugs Used for Down-Regulation
Akwai wasu magungunan da ake amfani dasu a cikin IVF don tabbatar da su. Suna da yawa kamar haka:
- GnRH agonists sun hada da kwayoyi kamar Lupron (leuprolide) , Synarel (nafarelin), da Zoladex (goserelin). GnRH agonists suna kwatanta yanayin hormone da ke faruwa a yanayin yanayi wanda ake kira hormone release-gonadotropin (GnRH) . Wannan shine hormone da ke haifar da ƙara yawan samfurin FSH da LH. Ta wurin ambaliya ta jiki tare da "GnRH" mai karya ", ovaries ya zama ƙarami kuma ya rufe rufe LH da FSH bayan kimanin makonni uku.
- Masu haɗaka GnRH sun haɗa da kwayoyi Antagon (ganirelix) da kuma Cetrotide (cetrorelix). Masu amfani da GnRH suna aiki ne ta hanyar ɗauri ga mai karɓa akan GnRH kuma ta hana ikon karɓar sakonni na kowane irin. Ta hanyar yin haka, an rufe FSH da LH kusan nan da nan.
Bayan shan magungunan GnRH don kwanaki da yawa ko makonni, za'a yi amfani da duban dan tayi don tabbatar da cewa mai launi na jikin mahaifa yana da ƙananan kuma qwai suna shirye su girbe. Sai a yi amfani da kwayoyi masu haihuwa don su kwantar da ovaries, bayan haka za a girbe qwai a karkashin maganin ƙwayar cuta.
Ƙarin Ma'anar Ƙasa-ƙira
Duk da yake ka'idodin da ake amfani da ita yana da mahimmanci wajen kawar da ovaries a lokacin IVF, ba ya aiki sosai ga dukan mata.
Wannan shi ne ainihin gaskiya a cikin mata da ƙananan garken ovarian (wanda ya rage yawan ƙwai).
Domin akwai matakan da za su yi aiki tare, magungunan GnRH zai iya yin aiki sosai. Maimakon yin watsi da ovaries, zasu iya kawo karshen sake zagayowar gaba daya.
Ga waɗannan mata, akwai wasu hanyoyin dabarun ƙwarewar ƙwayoyi za su yi amfani da su wajen cimma ka'idoji:
- Fara faramin kwantar da haihuwa na wata guda kafin IVF sannan kuma yayata ƙwayoyi don shawo kan aiwatarwar maturation da kuma kwayoyin halitta
- Bayar da maganin GnRH a ƙananan ƙwayar ko ƙananan kwanaki
- Fara GnRH jiyya fiye da yadda ya saba
- Farawa da kuma dakatar da injections GnRH a matakai daban-daban
- Ƙara ƙarin hawan gaggawa zuwa magani
A wannan lokacin, likita zai yi amfani da gwaje-gwajen jini da duban dan tayi don tantancewa da kuma daidaita tsarin ci gaba.
Sources:
> Badawy, A .; Wageah, A; El Gharib, M. et al. "Tsarin hanyoyi na tsarin Pituitary Down-Inganta IVF / ICSI Bincike a Matalautan Ovarian Responders" . 2012; 13 (3): 124-30.
> Magon, N. "Gonadotropin-releasing hormone agonists: Expanding vistas." Ind J Endocrinol Metab. 2011; 15 (4): 261-7; DOI: 10.4103 / 2230-8210.85575.