Me yasa wasu masanan kimiyya sun yarda akwai wata ƙungiyar ta bayyana
An ƙara mayar da hankali ga wani abu da ake kira maye gurbin MTHFR da ƙungiyoyi tare da mahalarta yanayin kiwon lafiya, wasu daga cikinsu suna da karfi da goyan baya kuma wasu daga cikinsu sun fi dacewa.
A cikin 'yan shekarun nan, wasu masu masana kimiyya sun nuna cewa maye gurbi zai iya bayyana dalilin da ya sa wasu mata suna ci gaba da ɓata .
Yayinda ka'idar ta kasance ba ta da cikakkiyar nasara, hakan ya haifar da rawar da kwayoyin halitta zasu iya yi a cikin ɓarna maras kyau, idan dai a cikin sashi.
Bayyana Harkokin MTHFR
Sauyawa na MTHFR wani abu ne a cikin kwayar halittar mutum wanda ke shafar ƙarfin jiki don samar da enzyme MTHFR. Harshen MTHFR, daga bisani, shi ne sinadarai da jiki ya samar ta yadda zai dace da acid acid (bitamin B9) .
Rashin rashin ciwon enzyme zai iya haifar da matsaloli masu yawa. Mafi tsanani ya kasance a cikin mutanen da suka gaji maye gurbin MTHFR daga iyaye biyu (halayyar da ake kira homozygosity), yayin da wadanda suka sami gado daya (heterozygosity) na da kaɗan, idan akwai, matsaloli masu ban mamaki. Samun maye gurbin MTHFR baya nufin cewa za ku sami wani rashin lafiya; shi kawai ƙara yawan haɗarin ku.
Wasu matsalolin kiwon lafiyar da aka danganta da maye gurbin MTHFR sun haɗa da:
- Homocystinuria, cuta wadda jiki ya kasa iya aiwatar da homocysteine, wanda yakan haifar da matsalolin ido, rikitarwa na jini mai rikici, ƙananan ƙwayoyin cuta, da matsalolin haɗin kai
- Anencephaly , nakasar haihuwa wanda ya ɓata ko ɓangaren ƙarancin kwakwalwa ko kwanyar
- Spina bifida, ƙaddamarwar kashi a cikin ƙananan igiya
- Maƙasudin haɗuwa da tsofaffi
Sauran karatu sun haɗa da maye gurbin MTHFR zuwa cututtukan zuciya, bugun jini, hauhawar jini, preeclampsia (cutar hawan jini a lokacin daukar ciki), glaucoma, cututtuka na psychiatric, da wasu irin ciwon daji. Yawancin waɗannan nazarin sun kasance sun haɗu. tare da ƙungiyoyin da aka samu a wasu amma ba a cikin wasu ba.
Dukkanin sun fada, MTHFR maye gurbin kwayoyin halitta suna da mahimmanci, tare da kusan rabin yawan jama'ar Amurka ana iya kasancewa a kalla heterozygous don maye gurbin.
MTHFR da Rashin Ƙari
Saboda shaidun da ke cikin yanzu yana da tallafawa sosai, akwai masana kimiyya da dama waɗanda suka kalubalanci ra'ayi cewa rashin kuskuren da maye gurbin MTHFR an haɗa su. Wadanda suke tallafawa ra'ayin suna yin haka bisa ga ƙara yawan rashin lafiyar mace tsakanin mata da wani bambanci da aka sani da maye gurbin MTHFR C677T.
Mahimmanci ga gardama shi ne muhimmancin da ake yi da homocysteine . Homocysteine ne amino acid da aka samar da ita ta jiki wanda ke taimakawa wajen samar da bitamin B. A gaban maye gurbin C677T, homocysteine ba za a iya sake sakewa ba kuma zai fara tarawa a cikin jini. Lokacin da wannan ya faru, zai iya haifar da wani mummunar yanayin da ake kira homocysteinemia wanda shine tushen haɗari ga cututtuka na jijiyoyin jini.
Wadanda suka goyi bayan ka'idar sun nuna cewa homocysteinemia zai iya haifar da samuwar karamin jini wanda ya kaddamar da kwandon abinci mai gina jiki ga mahaifa, da gaske yana fama da ciwon tayin kuma ya haifar da zubar da ciki maras kyau . Wannan ka'ida ne mai matukar rikicewa kuma daya wanda babu wata shaida mai wuya.
Da wannan aka ce, yawancin matan da ba tare da bata lokaci ba zasu gwada tabbatacce ga maye gurbin MTHFR. Kamar yadda irin wannan, wasu likitoci sun amince da amfani da kwayoyi masu rikici da suka hada da heparin da aspirin mai ragewa don rage hadarin jini. Wasu sun bada shawarar maganin asalin acid acid da sauran Bamin bit B, gaskantawa da zai iya samar da homocysteine manufa da hanyar da za a shafe ta daga jiki.
Duk da yake babu wata hujja da cewa kowane daga cikin wadannan matakan zai rage hadarin zubar da ciki, akwai kuma kananan shaidu da za su nuna cewa za su yi wani mummunar cuta.
Kalma Daga Verywell
A muhawara na ci gaba da fushi game da tasiri na mutuncin MTHFR a kan daukar ciki, jawabi na 2013 daga Cibiyar Kasuwanci na Obstetricians da Gynecologist ya bayyana cewa shaidun yanzu game da batun shi ne "iyakance" ko "wanda ba daidai ba" kuma ya shawarta akan amfani da kwayoyin MTHFR bincike ko azumi homocysteine gwaji a matsayin wani ɓangare na na yau da kullum jarrabawa gwaji .
> Sources:
> Kwalejin Amirka na Obstetricians da Gynecologists. "ACOG Yayi Shafin Labari N ° 138: Gidaran thrombophilias a ciki." Obstet Gynecol. 2013; 122 (3): 706-17. DOI: 10.1097 / 01.AOG.0000433981.36184.4e.
> Chen, M .; Yang, X; da kuma Lu, M. "Methylenetetrahydrofolate reductase din polymorphisms da kuma sake hasara mai ciki a kasar Sin: nazari na yau da kullum da kuma meta-bincike." Arch Gynecol Obstet . 2016 Feb, 293 (2): 283-90. DOI: 10.1007 / s00404-015-3894-8.